The concomitant use of opioids with other drugs that have an impact on the serotonergic neurotransmitter process has resulted in serotonin syndrome.

Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Resolution Suggest sufferers to appropriately eliminate unused Promethazine HCl and Codeine Phosphate Oral Remedy. Advise sufferers to toss the drug within the family trash following these actions. one) Eliminate them from their authentic containers and mix them having an unwanted substance, for example applied coffee grounds or kitty litter (this will make the drug considerably less attractive to little ones and pets, and unrecognizable to individuals who could deliberately go from the trash trying to get prescription drugs).

Medical scientific tests of Promethazine formulations did not consist of enough quantities of topics aged 65 and in excess of to determine whether or not they react in a different way from younger topics. Other described scientific practical experience has not discovered dissimilarities in responses between the elderly and youthful sufferers.

Antiemetics will not be advisable for therapy of uncomplicated vomiting in pediatric sufferers, as well as their use needs to be restricted to prolonged vomiting of identified etiology. The extrapyramidal indicators which could take place secondary to Promethazine HCl Oral Remedy administration might be puzzled With all the CNS signs of undiagnosed Main disease, e.g., encephalopathy or Reye's syndrome. The use of Promethazine HCl Oral Alternative need to be averted in pediatric sufferers whose symptoms and click here signs and symptoms may perhaps recommend Reye's syndrome or other hepatic conditions.

Promethazine and codeine may well result in marked drowsiness or could impair the psychological and/or Actual physical talents necessary for the overall performance of probably hazardous responsibilities, including driving a car or running equipment.

Codeine is known to get considerably excreted from the kidney, and the risk of adverse reactions to this drug may very well be bigger in individuals with impaired renal function.

There is absolutely no basic settlement about precise pharmacological treatment regimens for uncomplicated NMS.

Promethazine HCl Oral Remedy really should not be used in pediatric individuals under two a long time of age as a result of possible for deadly respiratory despair. Postmarketing instances of respiratory despair, such as fatalities, are already documented with usage of promethazine in pediatric individuals fewer than 2 many years of age.

Acute or extreme bronchial bronchial asthma in an unmonitored location or in absence of resuscitative tools. (four)

A heightened threat of unique malformations with codeine publicity for instance respiratory malformations, spina bifida and congenital coronary heart defects were being claimed in a few experiments.

Concomitant administration of Promethazine goods with other respiratory depressants has an association with respiratory melancholy, and sometimes Demise, in pediatric individuals.

Neuroleptic malignant syndrome (NMS) which can lead to Loss of life. Let you know healthcare service provider immediately In case you have any of the following signs of NMS:

Postmarketing situations of respiratory depression, which include fatalities have been reported with use of promethazine in pediatric people.

Promethazine is metabolized via the liver to a range of inactive metabolites for example sulfoxides of promethazine, N-demethylpromethazine along with other glucuronides.